Victora Lab@victora_lab

Victora Lab's mostly inactive twitter account

 New York, NY
germinal.center
Joined September 2020
1 Photos and videos
A new study from Rockefeller's Victora lab in @CellCellPress reveals how germinal centers produce powerful antibodies through noisy rounds of mutation and selection, offering new insight into vaccine design—and larger themes in evolution. 🔗: bit.ly/3Sor6Ve
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Victora Lab retweeted
Waggoner Lab@LabWaggoner
Jun 5
Replaying germinal center evolution on a quantified affinity landscape @CellCellPress @victora_lab @fredhutch @RockefellerUniv cell.com/cell/fulltext/S0092…
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What happens when you get that second shot on the same arm
Luka Mesin@LukaMesin
May 29
Read our latest preprint. A window into GC clonal evolution upon boost. biorxiv.org/content/10.64898…
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One more trick pulled off by antibody-mediated feedback cell.com/immunity/fulltext/S…

Antibody-mediated feedback modulates interclonal competition in the germinal center

Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the...

cell.com
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Congrats @JanaBilanovic, Alex Barbulescu, and all other authors!
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Save the date! keystonesymposia.org/confere…

B Cell and Antibody Responses | Keystone Symposia

Join us at the Keystone Symposia on B Cell and Antibody Responses, February 2027, in London, with field leaders!

keystonesymposia.org
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Victora Lab retweeted
Waggoner Lab@LabWaggoner
Jan 15
Replying to @biorxivpreprint
@biorxivpreprint One-step generation of TCR knock-in mice targeted to the TCRβ locus results in functional mature T lymphocytes @JoTraceyJa @UniOslo @ambilate @RockefellerUniv @JanaBilanovic @Victora_Lab biorxiv.org/content/10.64898…
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Victora Lab retweeted
HHMI
@hhmi_science
18 Nov 2025
Calling all rising juniors & seniors: Interested in biological or biomedical research? Apply now for our ’26 Summer Undergraduate Research Experience Program! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
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Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @JanaBilanovic biorxiv.org/content/10.1101/…

Antibody-mediated feedback modulates interclonal competition in the germinal center

Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response...

biorxiv.org
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Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by Will DeWitt (UW) and Tatsuya Araki and Ashni Vora (our lab), in a very close wet-dry collaboration with @ematsen ’s lab at the Hutch biorxiv.org/content/10.1101/…

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition...

biorxiv.org
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more replies
We took this idea seriously and applied it to germinal centers, evolving the same reaction over 100 times. No spoilers here, though I can tell you that the amount of data is huge, and some of the findings were pretty surprising. Please check out the preprint!
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Additional credit to multiple members of the Matsen, Victora, and other labs, especially @GallowayJared for coding; @tylernstarr and @jbloom_lab for deep mutational scanning; @WardLab1 for cryo-EM; and @TheArmita and @yun_s_song for help with math modeling
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