Today on the pod:
@lessin would rather send his kids to the military than to Andreessen Horowitz's new $35M school,
@Jessicalessin agrees on air, and
@davemorin ends up defending the thing he opened the segment by calling a marketing play.
Full house this week: Dave,
@brit, Jessica and Sam, plus
@Mazzeo of NoHo Labs, who spends most of the hour asking why none of them can be optimistic about anything.
Watch here on X or wherever you get your pods.
Topics:
00:00 Cold Open
01:14 Matt Mazzeo joins: peptides, CAA, and 15 years of Harvard connections
05:19 a16z puts $35M into a school: marketing play or higher ed reform?
06:20 Brit on every billionaire starting a university
08:21 Jess on Alpha School and who should be in charge of education
10:20 Sam: I'd rather send my kids to the military
12:19 Grit, great books, and learning to wrangle horses
16:40 Claude discovers a new enzyme system with 10,000 agents
18:01 Anthropic's IPO slips, and the liability problem
20:29 The story flip: from only we can be trusted to we can't afford the risk
21:14 Matt's maximalist take: long frontier, long open source
23:14 Massive demand, unclear profit, and the railroad pattern
24:40 Blackstone on who pays for the data center debt: we don't know
25:45 The Saint Petersburg paradox and pricing an infinite payout
27:56 Brockman redefines AGI, three years too late
31:11 Infinite demand doesn't mean infinite sustainability
32:20 Amazon blocks Muse: the first of many arms treaties?
35:37 Agents are quietly vaporizing the internet's breakage model
36:49 It's still 1982 for agents
37:42 Sam wants to spend thousands a month on CPU, not GPU
40:12 Does your agent represent you or the lab that made it?
42:16 When your agent does something bad, who is liable?
43:50 Peptides 101: what they actually are
46:30 GLP-1 revenue is rivaling AI revenue
48:20 How Matt went from 250 pounds to sub-12% body fat
50:29 The FDA is moving peptides back into compounding pharmacies
53:32 What a peptide protocol costs and how to start safely
57:17 Taylor Swift, girl dads, and a code for listeners