Stem cell biologist @MSKCancerCenter studying human PSCs for modeling development & disease and for cell therapy. Opinions are my own and do not represent MSK.

New York, NY
Congratulations to Shuibing for her new leadership position as Chair of Molecular & Medical Pharmacology at UCLA. The Tri-I stem cell community in NYC will miss you - but we are excited for you - and hope to continue collaborating on the next part of your scientific journey.
After 16 wonderful years @WCMSurgery , I’m deeply honored to share that I will join @UCLAHealth @dgsomucla as Chair of Molecular & Medical Pharmacology in March 2027. Excited for this new chapter of science, innovation, and collaboration!
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Congrats Josh on the MRF Resident Award!!
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Dr. @TabarViviane and Dr. @studerl, physician-scientists at MSK, have developed a treatment for #Parkinson’s disease that involves creating nerve cells from embryonic stem cells and transplanting them into patients. Early results show the treatment is safe and may improve Parkinson’s symptoms. "This is an important milestone on the road towards regenerative brain repair," says Dr. Tabar. "It represents more than two decades of collaborative work, based on very rigorous science beginning in our labs." Learn more: bit.ly/3EvfKbB bit.ly/4lxH2yC
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Things I wish more people knew about doing science in the US (thread):
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Congrats to @ZeltnerLab on their new paper. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration | Science Translational Medicine science.org/doi/10.1126/scit…. It was exciting to see this story develop from way back.
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👏 Congratulations to Dr. Deb Schrag, Chair of the @MSK_DeptOfMed, and Dr. @studerl, Director of the Center for Stem Cell Biology at MSK, who were elected to the @theNAMedicine, one of the highest honors bestowed upon scientists worldwide. Learn more: bit.ly/4fvwkoP
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📢 Join us! Developmental and stem cell biologists, checkout our tenure-track faculty position at Sloan Kettering. Apply by October 18. #DevBio #StemCell #hiringnow mskcc.org/research/ski/posit…
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This was a great episode indeed. Congrats to @bigosi and @TabarViviane
Replying to @stemcellpodcast
🥇 The top spot goes to Drs. Stefan Irion (@bigosi) and Viviane Tabar (@TabarViviane)! This episode was recorded live at @BlueRockTx and focuses on bemdaneprocel — a stem cell-derived investigational cell therapy for Parkinson’s disease! #InternationalPodcastDay bit.ly/3N2wMhV
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Congratulations to Dr. Shuibing Chen (@ChenShuibing) on her lab's new @CellStemCell paper! Her team developed vascularized macrophage-islet #organoids to study damage from infection. Read the article: bit.ly/4gqAcJ1 Learn more about her work 👇 bit.ly/3MuyPex
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Great postdoc opportunity if you are interested in developing next gen human PSC based cell therapies for brain repair here at MSK
We have a postdoc opportunity to work on cell therapy for #Parkinson’s disease in a highly collaborative environment @MSKCancerCenter @MSKEducation Apply at mskcc.org/research-areas/lab…
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Excited to see the work published @Nature. Excellent summary in thread below. Big collaborative effort with @ShenYingZhang1, @casanova_lab + many more. Special thanks to @yihaoo, @ZhiyongLiu7, Paul Bastard and in my lab @NoopurKhobrekar, Param Amin, @gabriele_ciceri & @harschnitz
1) Just out @Nature today! We show that human TMEFF1 is a restriction factor for #Herpes simplex virus 1(HSV1) in the brain, by limiting NECTIN1—HSV1-gD mediated HSV1 entry into cortical neurons. TMEFF1 defect can underlie HSV1 #encephalitis. nature.com/articles/s41586-0…
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Excellent thread from @ShenYingZhang1 on this new collaborative story, and for our lab one of the first studies to test run new hindbrain neuron protocol developed by @harschnitz
(1) We are happy to share our new study, “SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency” @JExpMed! doi.org/10.1084/jem.20231725. Accumulation of RNA lariats results in impaired antiviral immunity in hPSC-derived hindbrain neurons, underlying encephalitis. nitter.net/ShenYingZhang1/status/…
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Look, it’s the @studerl lab past and present at #ISSCR2024. Getting together is another awesome part of attending this conference 🤩
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Super excited to see this study finally published after many years of work. Congrats to @NatSaurat for the heroic effort and to all the many amazing collaborators who made this work possible. Also big thanks to our funders particularly the JPB foundation, NIA and @ASAP_Research.
How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA
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How to trigger age-related features in hPSC neurons? In a CRISPR screen @NatSaurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA
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Excellent thread from @_SoyeonKoo on the paper (and also her thesis work 😊). Congrats!
Excited to share that my doctoral thesis work is out in @CellCellPress We investigated a molecular driver to trigger hPSC-derived midbrain dopamine neurons during engraftment in mice.
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Replying to @CellCellPress
@CellCellPress @TaeWanKim0 @studerl Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease cell.com/cell/abstract/S0092…
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Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation. biorxiv.org/content/10.1101/…
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