Biological aging clocks as biomarkers of human aging: Biological basis, methodological design, and epidemiological implications sciencedirect.com/science/ar…

While we do not study apoptotic bodies in my lab, they are pretty cool! This cell expressing a membrane marker was videoed through a microscope while it was dying by @EmmaKoory. The video captured just the bottom of the cell. The cell rounds up as dying cells tend to do (i.e., it disappears from the region being imaged). Then apoptotic bodies come down and do cool stuff! In case you were wondering...... Yes, I am known internationally for my use of precise scientific language like "cool stuff" :-) #CellBiology

The Role of EVs in the Aging Hematopoietic System onlinelibrary.wiley.com/doi/…

According to Damasio & affective-homeostatic theories, interoception & homeostatic monitoring are essential to consciousness: subjective experience entails a mapping of the organism, the environment & the relationship between both. These forms of signaling are substrate dependent

What things should be in the inner loop? What things in the outer loops? What factorization takes the loop away entirely? What hardware wiring effecticely deloops a loop?

メタ認知の統合的神経科学 メタ認知は感覚/記憶などの不確実性を前頭前野中心の回路で自己の「確信度」へ変換し、誤り修正/学習/社会的判断/自己信念を調節 障害は現実認識や病識の異常に関与 #metya_cognition #papers nature.com/articles/s41583-0…

The Guardian: 'Abandoned, dismissed and gaslighted: there is no excuse for the way ME sufferers have been betrayed' By George Monbiot theguardian.com/commentisfre…

I catch so so so many mistakes in ai anything, it's crazy wild. Companies are going to need to hire people with pre AI experience and immaculate vibes. And we're starting to learn our premiums.

Our 🆕 paper alert ‼️ Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder our review published in @NatRevNeph @AranyLab @IntMedAbel @pei_liming @JosephABaur nature.com/articles/s41581-0…

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence onlinelibrary.wiley.com/doi/…

My flower painting

Immune cells fighting a long infection or cancer eventually burn out and stop working — a big reason some cancers escape the immune system entirely. Folks from St. Jude found a single gene acting as the burnout switch, and turning it off let exhausted immune cells snap back into fighting shape, dramatically improving survival in mice with cancer and chronic infections. nature.com/articles/s41586-0…

Nature paper identifying a new mechanism of how to kill #cancer cells. Shows that avermectin B1 which activates the PKCβ-MFF axis, which can sensitize tumours to ferroptosis in vivo. #immortabio @immortabio $IBRX nature.com/articles/s41586-0…

There is a significant lipid depletion (ether lipids, plasmalogens & cholesteryl esters) at baseline & after exercise in ME/CFS. (Christopoulos et al., 2026, ovid.com/jnls/acsm-msse/full…). This points to delayed aerobic recovery & persistent metabolic dysfunction underlying PEM #MECFS

Oh transgene silencing, how do I fix thee? Let me count the ways! Nifty new way of addressing transgene silencing!

Basket cells are inhibitory neurons that wrap basket-like terminals around nearby neurons, controlling their firing and synchronizing brain activity. They are generally credited to Santiago Ramón y Cajal, who described their basket-like axonal endings around other neurons.

Brain excitability could be two different things, not one. Two distinct excitability types delineate the partition between normal brain function, engram encoding, and the two phases of hyperexcitability/epileptic susceptibility nature.com/articles/s41598-0… #neuroscience

Averaging brain activity can hide important details. Here, they separated overlapping processes in real time. Signals of attention and preparation appeared across multiple brain regions and predicted participants’ accuracy and confidence. biorxiv.org/content/10.64898… #neuroscience

BRAINCELL 樹状突起supineや微細なglia突起を確率的に再現し細胞内外のion/伝達物質動態も統合する脳細胞simulation基盤 従来modelと異なる予測を示し神経-glia間相互作用の機序解析を可能に OA #network #soft #papers nature.com/articles/s41467-0…

The nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis | @ScienceTM science.org/doi/10.1126/scit…