Retired Haskell programmer. Was pro drummer & still play hours/day. Science, Philosophy, Literature. DMs blocked unless shared interests.
New Mexico, USA
Based in United States
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I asked Google AI and the last section is how to make XGboost part of a causal reasoning framework. There are papers for most.
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Great thread and the section on dysbiosis was so welcome and unexpected. A key metabolite that is produced by a healthy gut microbiome is butyrate. I started Tributyrin a precursor to butyrate because:
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Information about the different oscillation frequencies is spread out so Google AI put them together.
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Math is several languages, and that also helps.
1 functional and 1 logic programming (Curry is both)
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That's one great paper. Thank you so very much.
I was taking notes but then decided to use AI.
From this paper:
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Awesome. Thank you so very much.
I had inferred what I had posted to your last tweet.
Now, I decided to investigate and there are many papers about autistic hippocampal astrocyte dysfunction, what I had inferred. This is a summary of those papers.
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The paper mentions heparin as a therapy but heparan sulfate plays a critical role in vascular endothelial tissue.
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N-methyl-D-aspartate receptors (NMDARs) are involved in visceral pain and hypersensitivity, and can contribute to digestive upset, particularly in conditions like irritable bowel syndrome (IBS) and colitis. They are found in both the central and peripheral nervous systems, including the enteric nervous system, and play a role in regulating the release of neurotransmitters involved in pain.
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Creatine can only pass the BBB by way of the SLC6A8 transporter.
Creatine nasal spray bypasses the BBB.
But the brain has its own mechanism for creating creatine.
Creatine also improves cognition.
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Finally, in the discussion:
"Thymic involution leads to diminished naïve T cell production, while cumulative cellular and molecular defects impair T cell activation, proliferation, and memory formation1"
Thank you so very much for this. We elders appreciate it and you.
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This again is a most perfect complement to my interest. The mesoderm & bioelectricity is a also fascination.
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Entropy is a decrease-of-order & energy is free energy able to do work & work increases order. We are consumers of energy, food, heating, lawn mowers, lights, cars. All transformations of free energy into work.
Efficiency is an increase of work with constant energy.
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I downloaded the paper and had AI summarize it. I was so impressed with the Wnt activation/deactivation.
I Googled a section in my summary with "Glycolysis and Germ Layer Formation" and Google AI produced this including Wnt.
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There can be a stress response without stimulation. Walking out to sit is not a stress situation. There are however physiological triggers. So where to look.
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The Venice Biennale began in 1895.
Belgian artist @vera_kober_art abstracts essences of light and beauty.
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There are too many papers to cite so Google AI read them all and produced this. Google AI also said, in a separate prompt, that cancer cells secrete PD-L1 ligands into the TME.
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Thank you so much for reposting. I wanted to go back to this highly impressive paper but had lost track of it.
I'd bought curcumin Longvida® for max absorption but didn't know about these analogs. I am religious about pterostilbene since early 2020.
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March 2023 article
Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?
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There was some misinformation of only a small percentage of Federal research funding making it to university labs. Not all funds go to the labs.
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I tried to summarize just the first paragraph without losing meaning or logic and again failed miserably.
There are several paper on MLV & glymphatic clearance.
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The paper is part of a book series. I Googled "Taurine and calcium homeostasis" Taurine passes through the BBB to the DNS & regulates calcium.
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This is a comprehensive paper that will resonate with the cognizant. It is beyond homeostasis and even beyond standard systems because of the intelligence & goal directedness of the collectives. Cascades (my fav) are very much broader than cellular.
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I have no material. I watched a video recently of
a microbiologist and she peaked my interest but when I can read, I do not know. Empathy in animals is from observation and experience.
The following Google AI is for the bacteria. Its an amalgam of many papers are resources.
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This made me look up P53 and ME/CFS because the multiple possible viral components of ME/CFS/LC.
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Nucleotides map to amino acids in a very consistent manner, the sequence is what varies. This is, of course, translated in RNA then converted to amino acid sequences, that is, protein.
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There was a response to one of her post that said he took some substance to clear it & I liked it but now can't find it.
The meditations pretty much work in the same way, increasing GABA & serotonin. GABA & 5-HTP are OTC.
I asked Google AI for meds
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Part is thoroughly modern but compositionally classical.
His minimalist style and rhythms are in stark contrast to Mahler but still quite enjoyable and even more interesting.
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Astrocytes are key regulators of brain energy metabolism, with a crucial role in supporting neuronal activity/brain function. They primarily use glucose for energy, shuttling lactate to neurons for oxidation. They also metabolize amino acids & lipids for fatty acid oxidation.
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As a post here decrying the anti-cancer effects of metformin I responded with whatever metformin can do, berberine can do more and better.
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Super paper, Thank you.
Maybe more implied is the mitochondrial determination of immune cell phenotype. These Google AI outlines are well cited.
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TY for this!!
The paper is heavily watermarked but an amount of OCD accompanies ADHD & my AI tools are on the fritz or unlearned so Google AI produced a summary of a few papers with this one on top. Monocyte derived macrophage can also destroy myelin. Wnt is out of character here.
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Broad spectrum antibiotics also destroy the gut microbiome.
I hadn't realized nettle leaf is antihistamine and anti-inflammatory. I've organic leaf I mix with black tea to start using again.
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Under normal oxygen conditions (normoxia), prolyl hydroxylase domain (PHD) enzymes hydroxylate HIF-1α, marking it for degradation, but inhibiting PHDs stabilizes HIF-1α, mimicking a hypoxic state.
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Thank you so very much again. This clarified thought, I was interested in this paper but wasn't clear why.
I googled "genetic nuclear factors in adipose bone marrow is myeloid biased change"
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Vascular endothelial cells oxygenate tissue but like axons and RBCs rely on glycolysis instead of oxphos.
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In PMC this article had these similar articles.
They are a bit aged but full of interesting facts.
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I'm now almost done with the M's
I recently installed the "vertical tabs" plugin and it's what's helping me decide bookmark or not. It's much like organizing books. They are also so dang much fun to read.
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In normoxic conditions, inhibiting Prolyl Hydroxylase Domain 2 (PHD2) activity mimics hypoxia by stabilizing the HIF alpha subunit, leading to a hypoxia-like response and triggering HIF-dependent transcriptional activation.
PHDs are the O2 sensors controlling HIFs.
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