#SARSCoV2 reactive CD4 T cell response have been identified in unexposed humans. We now provide direct evidence that pre-existing immune memory can be derived from exposure to #commoncold coronaviruses science.sciencemag.org/conte…

Aug 4, 2020 · 4:29 PM UTC

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Replying to @SetteLab
So our maskless ancestors have saved us? Can’t wait until we see what next year brings with all the social distancing and mask wearing. Seems ripe conditions for an immune forest fire.
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Replying to @SetteLab
What is the most plausible prior as to whether this pre-existing reactivity is likely to be protective?
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Replying to @SetteLab
Where does Professor Levitt go to get his apology?
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Replying to @SetteLab @BallouxFrancois
@SaulFaust
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Replying to @SetteLab
@abantika77
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Replying to @SetteLab
Perhaps we should give everyone common cold coronaviruses to help build immunity? I would gladly volunteer
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Replying to @SetteLab
In the late 1980s & early 90s, emergence of a mild porcine respiratory CoV closely related to the virulent Transmissible gastroenteritis virus in pigs led to decline in incidence of the latter. Pigs exposed to PRCoV developed partial immunity to TGEV, led to decline in outbreaks
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Replying to @SetteLab
I am wondering what this would mean for teachers who are exposed to everything in their classrooms.
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Replying to @SetteLab @BallouxFrancois
Is this why the East hasn't suffered as much as the west? Pre-existing immunity built up over the years
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Replying to @SetteLab
Congratulations Alex, great work. Perhaps explains why younger people have a much milder course.
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Replying to @SetteLab
Any possibility that the reaction might be due to exposure to unidentified previous zootronic infections as suggested here?.. blogs.sciencemag.org/pipelin…
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Replying to @SetteLab @labratprats
It is likely OX40/CD137 staining alone is missing many more x-reactive T cells in unexposed individuals, essentially undercounting the actual level of pre-existing T cell immunity to #codiv19.
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Replying to @SetteLab
So I could have been correct that the best prevention currently is giving people a dose of common cold? I was being a bit facetious when I stated it.
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Replying to @SetteLab
Makes sense and when you get older you start losing that level of protection especially after 65-70. Guess I am lucky to be exposed to 200 patients a week in my office the whole time then.
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Replying to @SetteLab
Ah finally. I have been waiting for these results. Greetings! I have always admired your work, and have been citing you since 2010. It is just appropriate that these studies came out of your lab 🙇‍♀️ I wonder how it will look with CD8+ epitopes 🤔🙂
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Replying to @SetteLab @BallouxFrancois
I’ve had lots of colds and respiratory viruses they have knocked me off my feet and I have the flu jab every year. I think I catch everything that’s going !
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Replying to @SetteLab
So. Lets find those infected with other Corona Viruses and make them superspreaders. At least some might become inmune. Right?
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Replying to @SetteLab
👏👏👏🔥
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Replying to @SetteLab @BallouxFrancois
Congratulazioni, un ottimo studio e bellissimi risultati.
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Replying to @SetteLab
@BallouxFrancois
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Replying to @SetteLab @TomFitton
Because coronavirus is the common cold.
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Replying to @SetteLab @zbiotech
Can this explain why in the antigen sero tests in various cities/states across the world a much higher 5x to 10x people test positive?
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Replying to @SetteLab @BallouxFrancois
Thank you for forwarding!
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Replying to @SetteLab @twawki2
I think it was SARS and exposure to canine coronavirus. So go pat a dog, get dirty and shake lots of hands. It is good for us.
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Replying to @SetteLab @TomFitton
How long will this be up before Twitter removes it?
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Replying to @SetteLab
T cells kick ass.
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Replying to @SetteLab
science.sciencemag.org/conte…
Replying to @SetteLab
How long does common cold immunity last on average?
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Replying to @SetteLab @venivici27
This is just in vitro simulation. Not human study.
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Replying to @SetteLab
Interesting research.
Replying to @SetteLab
@tylercowen
Replying to @SetteLab @guillesequera
Dr que significa esto ?
Replying to @SetteLab @allisonpearson
Does this mean that having had common colds every year might give a degree of immunity from SARS-COV-2?
Replying to @SetteLab
@DrowsyRebel have you read this?
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Replying to @SetteLab @TomFitton
JUst read the last sentence. Published 05/19/2020
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Replying to @SetteLab
This is an important finding. The implication is any sort of immunity + observance of public health practices could potentially reduce community risk and spread significantly.
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