First dose of Repatha 8/8 Returning to my infant level ApoB

We're done with KETO-CTA (for now) piped.video/s5iUg_eF--I?is=FGBx… via @YouTube

There is an entire supermarket aisle built for babies, and almost none of it is recommended by anyone in paediatrics or nutrition. In part two of my conversation with Dr Federica Amati, Head Nutritionist at ZOE, we go through birth and the C-section question, breastfeeding versus formula, weaning and first foods, and the microplastics story that sits behind all of it. What I keep taking from her is that this window is critical without being fragile, and that the guilt aimed at parents belongs somewhere else entirely. For the full show notes head to: theproof.com/birth-breastfee…

Can You Reverse Liver Scarring? Fatty Liver, Fibrosis & Recovery Explain... piped.video/mtrwb6Pt9d0?si=FZge… via @YouTube

It’s just mind-blowing the results you can obtain in a patient with class 1/3 obesity who eats a Mediterranean diet, does resistance training, stays away from alcohol, and takes Tirzepatide. We are so lucky to be practicing medicine in 2026

These book promotion bots on YouTube are nauseating

Eudemonia 2026. Catch you there 🫶🏻

Just recorded another awesome episode with Dr Nicola Guess. Episode will be out in a few weeks on Youtube - subscribe below piped.video/@TheProofWithSim…

It's possible that protein differences explain (at least part of) the difference in liver fat between these 3 diets. sciencedaily.com/releases/20…

This article explores whether BMI should be replaced for ascertaining excess body fat in cardiovascular prevention or whether BMI could still keep its prominent role.

As a male and an antinatalist, I have serious issues with pregnancy and creating new humans without getting their permission (which is, of course, impossible to get). However, this is an enjoyable, informative and important conversation with @theproof. Highly recommended.

Dr Federica Amati is back on The Proof in this weeks episode How Pregnancy, Breastfeeding & Baby Food Shape Lifelong Health | Dr Federica Amati | EP#437 piped.video/_azT7mpHL-Q

Human trials on OJ disagree: - Fatty liver: no worsening of liver markers (PMID: 27414418) TG/VLDL: no ↑ TG (PMID: 37008412) Insulin resistance: HOMA-IR ↓ (PMID: 34060162) Uric acid: ↓ despite high OJ intake (PMID: 29571566) Adiposity: no ↑ fat mass/waist (PMID: 34024506)

Can Liver Scarring Be Reversed? Steatotic Liver Disease and Fibrosis Explained | Aleksander Krag piped.video/mtrwb6Pt9d0

Fibremaxxing with fruits and vegetables. I increased my fibre by approx 15g a day and my triglycerides, Hba1C, fasting insulin and fasting glucose all fell. Triglycerides - 50mg/dl Fasting blood glucose - 72 mg/dl Hba1C - 5.1% Fasting insulin - 1.6 uIU/ml Overall I’ve achieved these metabolic numbers with a diet that is: Rich in fibre (with a fibre supplement) Rich in unsaturated fats Moderate to high protein And I reduced my ApoB from 80 mg/dl to 50 mg/dl with a pcsk9 inhibitor #metabolichealth

This is actually easily explainable and it isn't the "dunk" or whatever some people think it is. At the most fundamental level, linoleic acid (LA) concentration and percentage are separate biological variables. You can see this with a simple hypothetical: the first person is metabolically healthy while the second person isn't. Healthy person: Total fatty acids = 4 mmol/L LA = 1.2 mmol/L LA = 30% of total Unhealthy person: Total fatty acids = 8 mmol/L LA = 1.6 mmol/L LA = 20% of total The LA concertation increased by 33% in the unhealthy person, but the percentage decreased from 30% to 20%. And this would result in the exact thing you see among these graphs, where higher metabolic risk correlates with both higher LA concentrations and lower LA percentage. This is almost certainly what was happing in the NHANES cohort from this study because total circulating fatty acid concentrations were positively correlated to triglyercides, LDL, cholesterol, insulin, glucose, blood pressure, BMI, and waist circumference. And LA increased as total fatty acids increased, but not nearly as quickly, meaning that percentage of LA fell while concentration of LA increased as someone became more metabolically unhealthy. Basically, LA concentration may simply be inheriting the association between total circulating fatty acids and metabolic dysfunction. Just take a step back here and imagine someone with insulin resistance. These people have a larger circulating pool of fatty acids overall, including LA. So of course LA concentration tracks with insulin, just like nearly every other fatty acid. So, if anything, these results aren't evidence that LA concentration is itself harmful.

I have a great guest booked in for an upcoming episode on Cardiovascular-Kidney-Metabolic (CKM) Syndrome Have you heard of this?

This study looking at a ketogenic diet and MASLD seems to have received minimal air time. Quality research group including Gerald Shulman and Hannele Yki-Järvinen. The keto diet induced greater liver fat loss than the non ketogenic diet (similar to Sam Kleins recent study) But there's more to the story as detailed by the authors below: "The effects were more pronounced with KD, reflecting its induction of a starvation-like metabolic state. However, these benefits were accompanied by suppression of hepatic mitochondrial TCA cycle oxidation and increased hepatic mitochondrial redox state – features previously linked to progressive liver injury. journal-of-hepatology.eu/art…